09:00 - 18:00
Исследования осуществляются ООО "ПраймБиоМед" при грантовой поддержке фонда "Сколково"

Mouse monoclonal anti-E-Cadherin (ECAD) antibody, clone PBM-2E12

Catalog Number 10-310056

Marker binding E-Cadherin (ECAD)

Alternate Names

    •  Epitelial cadherin

    •  Cadherin 1 Type 1

    •  E-cadherin

    •  CD324

    •  CD 324

    •  CDH1

    •  Arc1

    •  ECAD

    •  CDH-E

    •  E-CAD

    •  LCAM

    •  UVO

    •  Uvomorulin

    •  Calcium-Dependent Adhesion Protein

    •  Liver Cell Adhesion Molecule

Type Monoclonal

Clone E-Cadherin (ECAD)

Host Mouse

Species Reactivity Human

Usage Statement RUO (Research use only)

Suitable for IHC-P, WB

Demasking of antigens According to the datasheet

Isotype IgG1

Antigen ECAD, full size recombinant protein

Localisation Cytoplasmic

Positive control Prostate adenocarcinoma

Storage conditions 2-8 °C

Description

E-Cadherin is a 120 kDa transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells. There, it interacts with the cytoskeleton through the associated cytoplasmic catenin proteins. E-Cadherin is a critical regulator of epithelial junction formation. Its association with catenins is necessary for cell-cell adhesion. These E-cadherin/catenin complexes associate with corical actin bundles at both the zonula adherens and the lateral adhesion plaques. E-Cadherin expression is often down-regulated in highly invasive, poorly differentiated carcinomas. Increased expression of E-Cadherin in these cells reduces invasiveness. Thus, loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression. E-cadherin used for differential diagnosis between ductal and lobular breast carcinoma.

Packaging

    •  0.1 ml conc. (recommended dilution 1:100)

    •  0.5 ml conc. (recommended dilution 1:100)

    •  1 ml conc. (recommended dilution 1:100)

    •  7 ml diluted, ready to use (RTU)