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Mouse monoclonal anti-Cytokeratin 20 antibody,
clone PBM-3Н5

Catalog Number 10-310051

Marker binding Cytokeratin 20

Alternate Names

    •  Cytokeratin 20

    •  Keratin 20

    •  CK-20

    •  KRT20

    •  K20

    •  KRT21

Type Monoclonal

Clone PBM-3Н5 (3Н5)

Host Mouse

Species Reactivity Human

Usage Statement RUO (Research use only)

Suitable for IHC-P

Demasking of antigens According to the datasheet

Isotype IgG2a

Antigen CK20, full size recombinant protein

Localisation Cytoplasmic

Positive control Colon adenocarcinoma, appendix

Storage conditions 2-8 °C

Description

Cytokeratin 20 is an intermediate filament protein with a molecular weight of 46 kDa, the expression of which is mainly limited to the epithelium of the stomach and intestines, urothelium, and Merkel cells. Cytokeratin 20 is a unique type I keratin that is expressed in adenocarcinomas of the colon, stomach, pancreas, and gallbladder. It is also expressed in ovarian mucinous tumors, transitional cell carcinomas of the urinary tract, and Merkel cell carcinomas. CK20 is practically non-reactive in squamous cell carcinomas and adenocarcinomas of the breast, lungs and endometrium, as well as in non-mucinous ovarian tumors and small cell carcinomas. Cytokeratin 20 is often used in combination with CK7 and other antibodies to differentiate colon carcinoma (CK20 +) from ovarian, lung, and breast cancers.

Packaging

    •  0.1 ml conc. (recommended dilution 1:100)

    •  0.5 ml conc. (recommended dilution 1:100)

    •  1 ml conc. (recommended dilution 1:100)

    •  7 ml diluted, ready to use (RTU)