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Исследования осуществляются ООО "ПраймБиоМед" при грантовой поддержке фонда "Сколково"

antibody MLH1, clone (GM011) Mouse

antibody MLH1, clone (GM011) Mouse

Catalog Number
10-310018
Antigen
MLH1
Host
Mouse
Clone
GM011
Isotype
IgG1
Method
IHC / Immunofluorescence
Epitope retrivial
Proteinase K
Localisation
Nuclear
Positive control
Colon,
Keep conditions 2-8C 
Full description
MLH1 is deficient in a high proportion of patients with microsatellite instability (MSI-H). It has been
shown that immunohistochemical analysis of MLH1 expression is a practical and reliable method
for the routine detection of the vast majority of colorectal carcinomas with high-frequency MSI,
which are frequently identified in hereditary nonpolyposis cancer (HNPCC) and are account for
15% of sporadic colorectal cancer. MLH1 negative tumors maybe associated with a longer
disease-free survival.
References
1. Bronner CE, et al. Nature. 1994 Mar 17;368(6468):258-10
2. Lanza G, et al. Mod Pathol. 2002 Jul;15(7):741-9.
3. Marcus VA, et al. Am J Surg Pathol. 1999 Oct;23(10):1248-055.