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Antibodies to p53 , clone (BP-53-12) mouse, concentrated

Antibodies to p53 , clone (BP-53-12) mouse, concentrated

Cat #
10-310009-1
Antigen
p53
Source
mouse
Clone
BP-53-12
Isotype
IgG2a
Configuration
concentrated
Method
IGH (FZP or frozen)
Dilution
1: 100
Antigen unmasking
Thermal, Citrate buffer pH 6
Reactivity
Man. The rest is unknown.
Localization
Nuclear
Positive Control
Colorectal Cancer
Authorized Use
RUO
Packing
1 ml
Storage Conditions
2-8 ° C

Full description
Antibodies bind to normal and mutant type p53 protein and are used to detect increased expression of p53. For many tumors, p53 detection has important prognostic value Normal p53 protein is expressed in various healthy cells, but, in due to the extremely low half-life, it is not detectable with using standard immunohistochemical methods. Somatic mutations The p53 gene is often found in various tumor processes. Mutant p53 protein is more stable than unchanged, and accumulates in the tumor cells in significant concentration.
Links

1. B? Rtek J, et al. J Pathol. 1993 Jan; 169 (1): 27-34. 2. Terada T, et al. Mod Pathol. 1994 Feb; 7 (2): 249-52. 3. Suzuki H, et al. Cancer Lett. 2006 Jun 18; 237 (2): 242-7. Epub 2005 Aug 18.


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